منابع مشابه
Biosynthesis of monensin.
The biosynthesis of monensin by Streptomyces cinnamonensis was studied by using (14)C-labeled glucose, acetate, propionate, butyrate, and methionine. The results indicated that the antibiotic is synthesized from five acetate, seven propionate, and one butyrate molecules. The o-methyl group of monensin is derived from methionine, whereas the terminal hydroxymethyl group is incorporated from acet...
متن کاملMonensin and Proinsulin Biosynthesis
Monensin, a specific sodium ionophore~ has been shown to reduce glucose-induced proinsulin biosynthesis by 30% and to completely inhibit ~he intracellular conversion of proinsul in to insulin. Autoradiography of monensint r e a t e d cells d e m o n s t r a t e d the p resence of large quantities of newly synthesized proteins in amorphous vesicles close to the Golgi complex of B ceils. The r e ...
متن کاملIntermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding
Polyether antibiotics such as monensin are biosynthesised via a cascade of directed ring expansions operating on a putative polyepoxide precursor. The resulting structures containing fused cyclic ethers and a lipophilic backbone can form strong ionophoric complexes with certain metal cations. In this work, we demonstrate for monensin biosynthesis that, as well as ether formation, a late-stage h...
متن کاملMonensin-resistant bacteria in the rumens of calves on monensin-containing and unmedicated diets.
Total and monensin-resistant anaerobic bacterial populations and volatile fatty acid concentrations were examined in the rumens of steers fed monensin-containing (33 mg/kg) and unmedicated diets. Total anaerobic counts on a habitat-simulating medium ranged from 7.1 X 10(8) to 7.1 X 10(9) CFU/g of rumen ingesta and were not significantly different in animals fed the two diets. The mean percentag...
متن کاملMonensin for Range Beef Cows
in the last. Bermuda hay made up a large part of the total dry matter intake during the last 47 days of the trial. Daily intake of protein should have been very adequate in the early part of the test, but would have declined to marginal levels during the last 56 days due to the weather related failure to grow green forage. The overall response to providing 200 mg. of monensin to cattle grazing ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1973
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.4.4.410